My passion is to bridge the gap between biology, engineering and nanotechnology, to develop simple, inexpensive, easy-to-use, yet, broadly applicable platforms that will change the way in which medicine is practiced as well as how patients are monitored, diagnosed and treated for precision medicine. I apply key biological principles to engineering designs. This effort, for the first time, offers to integrate magnetic levitation profiling of cells with molecular biology, transcriptomics and proteomics, which are traditionally basic-science disciplines, within the milieu of precision medicine. Interfacing my unique bioengineering platforms with next-generation sequencing technologies, I aim to understand and answer fundamental questions mainly in cancer biology and antibiotic resistance.
My focus is to develop new tools and technologies to investigate and fundamentally understand disease and wellness. My research efforts are summarized as follows:
- Creating new tools and technologies to detect and isolate circulating biological signatures, materials and markers from biological fluids (i.e., circulating tumor cells, circulating tumor emboli, exosomes in blood, urine, and saliva).
- Enabling investigations of these rare biological materials to “decode” the molecular, genetic and proteomics characteristics to better understand the biology of disease, with a special focus on cancer biology and metastasis.
- Evolving these technologies into the next generation of applications in antibiotic resistance to eradicate biofilms and resistant microorganisms.